Formulation Challenges? We offer Innovative SYLOID Silica Excipients
Silica excipients are more than just processing aids. The right excipient can substantially impact manufacturing efficiency, dissolution, therapeutic effectiveness, and stability of the final dosage form.
Choosing the right excipient early in the process helps reduce time to market and improves the chance of commercializing an NCE / NBE or generic APIs.
W.R GRACE has a broad portfolio of excipients and technologies to optimize drug formulation and purification. SYLOID® silicas can improve flow properties for direct compression and prevent valve blockage.
SYLOID® Silica: The solution to formulation challenges
SYLOID® Mesoporous Silica's unique, innovative design combines adsorption capacity, particle size, density, and internal surface area to provide multifunctional benefits. This silica is designed to reduce the number of ingredients and simplify drug formulations, making production faster and improving the application. It also helps powders flow better during manufacturing, even in different humidity levels, and prevents clogging in valves.
The higher density of SYLOID® Silica means less dust, which makes it easier to meet GMP standards and store more efficiently.
The higher density of SYLOID® Silica means less dust, which makes it easier to meet GMP standards and store more efficiently.
Main Benefits of SYLOID® Silica:
• Better Flow allowing powders to move smoothly during manufacturing
• Prevents degradation of moisture sensitive APIs and natural actives
• Helps tablets dissolve better, and stay stable longer.
• Less dusty- reduced potential for cross contamination
• Acts as an anti-static agent and reduces API/ANI loss
• Prevents sticking – anti-tacking agent
• Carrier for oily ingredients, making them easier to handle in tablets
• Carrier for oily ingredients, making them easier to handle in tablets
• Prevents tablets from sticking together during coating, improving quality.
GRACE's manufacturing process creates particles with highly defined pore structures, resulting in an internal porosity that can be modified to deliver outstanding adsorption, porosity, particle size distribution, and greater internal surface area for functionality.
SYLOID Silica - Greater density benefits:
SYLOID® mesoporous silicas are used in a wide range of applications, including:
• Moisture protection
• Improved flow through the reduction of electrostatic charging
• Moisture-Assisted Dry Granulation (MADG)
• Liquisolid formulations
• Oil absorption in lipid-based technologies (Self-emulsifying drug delivery systems, SEDDS)
SYLOID® silica’s greater density creates less dust for easier GMP compliance and more compact storage. These solutions offer formulation value and improves profitability
SYLOID® Silica solutions also offer manufacturers cost savings.
✅ Increased bulk density
✅ Smaller containers & less storage needed
✅ Increased bulk density
✅ Smaller containers & less storage needed
✅ Streamlined storage
✅ Reduced shipping costs
Grace’s SYLOID® mesoporous silicas are used to boost solubility and absorption. Their particle properties—like pore size, volume, and surface area—can be adjusted to fit specific formulation needs.
SYLOID® FP and XDP – What’s Special?
SYLOID® FP: Designed for moisture-sensitive drugs; absorbs moisture and improves tablet strength, flow, and stability.
SYLOID® XDP: Ideal for oily or lipid-based drugs; turns liquid formulations into solid powders without needing solvents or drying.
See our offerings for GRACE's SYLOID® FP and XDP grades below:
SYLOID® 244 FP
To address the challenges associated with moisture and blend flow in pharmaceutical and nutritional ingredients, Grace designed the specialized multifunctional, mesoporous excipient SYLOID® 244 FP/F. The uniquely designed mesoporous structure provides access to the large internal surface area which defines its performances:
To address the challenges associated with moisture and blend flow in pharmaceutical and nutritional ingredients, Grace designed the specialized multifunctional, mesoporous excipient SYLOID® 244 FP/F. The uniquely designed mesoporous structure provides access to the large internal surface area which defines its performances:
• Improves flow for both standard & challenging formulations
• Less dust, reducing the potential for cross contamination
• Less bulky, easier to handle and store
• Reduces downtime from static buildup
• Eliminates or reduces need for sieving prior to use
• Improves glidant properties and homogeneity
SYLOID® 63 FP
Controls trace amounts of moisture and moisture transfer from the surrounding environment which can degrade APIs or cause reactions that negatively impact drugs or decrease shelf life.
SYLOID® 72 FP
An advanced mesoporous silicon dioxide formulated by GRACE to provide a moderate pore volume, large internal surface area, and bulk density of 0.16 g/cc. High-performing excipient for multiple applications.
Patented SYLOID® XDP silica is an effective carrier for Oils and SEDDS
Syloid XDP is available in two particle sizes 3050 and 3150
SYLOID® XDP 3050
a high-performance silicon dioxide-based excipient agent used in the formulation of pharmaceuticals and nutraceuticals. Its controlled particle size and high porosity makes it the ideal carrier for lipids.
SYLOID® XDP 3150
a high-purity silica powder offering superior adsorption power, 1 to 1.5 times its weight in liquid, while remaining free-flowing and non-dusty for pharmaceutical and nutraceutical applications.
SYLOID® FP Silica - Film Coatings Benefits
✅ Improved suspension stability (replace talc and add 2-3%)
✅ Helps prevent blockage of valves and spraying nozzles
✅ Anti-tacking agent (replace talc)
✅ Increases permeability of film coating (SYLOID® AL-1FP / 244FP silica, add 10% or more)
SYLOID® FP silica results in brighter tablets with a better colour dispersibility at much lower solid % in tablet coating formulations
Grace-Pharmaceutical-Solutions-Brochure.pdf
Review Grace's product selection guide for both pharmaceuticals and food & nutraceutical applications below:
