SYLOID® Silica: Multifunctional excipients
SYLOID® Silica: One Excipient, Multiple Formulation Solutions
Addressing Today's Pharmaceutical Formulation Challenges
Formulators face increasing pressure to develop stable, effective, and commercially viable products while reducing development timelines and manufacturing complexity. Moisture-sensitive APIs, poor powder flow, oily actives, tablet variability, and coating challenges can negatively impact both product performance and manufacturing efficiency.
Selecting the right excipient early in development can significantly improve formulation success, reduce time-to-market, and support the commercialization of both innovative and generic drug products. SYLOID® mesoporous silica excipients from Grace are engineered to address multiple formulation and processing challenges with a single multifunctional ingredient.
Why SYLOID® Mesoporous Silica?
Unlike conventional silica excipients, SYLOID® silica features a highly engineered porous structure with controlled pore size distribution, high internal surface area, and optimized particle characteristics. These properties enable formulators to achieve multiple benefits from one excipient while simplifying formulation design.
Key Benefits
✅ Moisture protection and stabilization of sensitive APIs
✅ Improved powder flow and direct compression performance
✅ Enhanced manufacturing efficiency
✅ Reduced sticking, caking, and static buildup
✅ Improved tablet hardness and reduced friability
✅ Oil and lipid adsorption for solid dosage conversion
✅ Better coating performance and suspension stability
✅ Reduced formulation complexity and excipient load
Applications
✅ Moisture management and stabilization
✅ Powder flow enhancement
✅ Direct compression applications
✅ Moisture-Assisted Dry Granulation (MADG)
✅ Tablet coatings
✅ Lipid-based formulations and SEDDS
✅ Conversion of oily APIs into free-flowing powders
✅ Flavor and oxidative protection
By delivering several functional advantages simultaneously, SYLOID® silica helps formulators create simpler, more robust formulations while improving product quality and manufacturing performance.
Moisture Control and Stability - SYLOID® 63 FP
Protect Moisture-Sensitive Formulations
Even small amounts of moisture can impact pharmaceutical products by accelerating chemical degradation, reducing potency, affecting physical stability, and shortening shelf life. SYLOID® 63 FP is a high-purity synthetic amorphous silica designed to manage moisture while improving powder flow and manufacturing performance.
Benefits
✅ Adsorbs and controls trace moisture
✅ Protects moisture-sensitive APIs
✅ Prevents caking and agglomeration
✅ Improves blend uniformity
✅ Enhances powder flowability
✅ Supports direct compression processes
✅ Improves tablet consistency
✅ Extends product stability and shelf life
Compatible with a wide range of dosage forms and ingredients, SYLOID® 63 FP provides a versatile solution for pharmaceutical and nutraceutical manufacturers seeking reliable moisture control.
Flow Enhancement and Manufacturing Performance - SYLOID® 244 FP
One excipient. Many functions. Total formulation support
SYLOID® 244 FP is a versatile mesoporous silica excipient designed for tablets, capsules, powders, and coating applications. Its unique pore structure and particle morphology provide multiple formulation and processing benefits in a single ingredient.
Features of SYLOID® 244 FP silica:
6μm discreet particle size | Density significantly higher than fumed silicas | Excellent glidant performance | Improved handling characteristics
Features of SYLOID® 244 FP silica:
6μm discreet particle size | Density significantly higher than fumed silicas | Excellent glidant performance | Improved handling characteristics
Key Functions
🧬 Glidant - Enhances powder flow and reduces stickiness
Sample SYLOID® 244 FP🧬 Glidant - Enhances powder flow and reduces stickiness
🧬 Anti-Caking - Prevent moisture pickup, keep blends free-flowing
🧬 Anti-Electrostatic - Reduce API loss from static and sieving
🧬 Moisture Protection - Improve stability in moisture-sensitive APIs
🧬 Tablet Strength - Increase hardness, minimize capping / lamination
🧬 Anti-tacking - Ensure smooth and clog-free tablet coatings-talc-free
🧬 Flavour stability - Protect taste, limit oxidation
🧬 Oil to Powder Conversion - Transform oily APIs to powders
Performance Advantages
Improves powder flow in challenging formulations
Reduces dust generation and handling issues
Minimizes static buildup and API loss
Increases tablet hardness
Reduces friability, capping, and lamination
Improves blend homogeneity
Supports coating suspension stability
Can replace talc in film-coating systems
Compared with conventional silica technologies, SYLOID® 244 FP delivers superior bulk density, easier handling, and improved flow performance while supporting consistent tablet weight and quality.
Lipid and Oil-Based Drug Delivery - SYLOID® XDP
Transform Oily APIs into Free-Flowing Powders
Many modern APIs and delivery systems involve oils, lipids, or poorly water-soluble compounds that present processing challenges.
SYLOID® XDP was specifically developed to convert oils, lipid formulations, and oily active ingredients into stable, free-flowing powders without the use of solvents.
Ideal For:
Lipid-based formulations | Self-emulsifying drug delivery systems (SEDDS) | Solid dispersions | Semi-solid formulations | Oil-based drug solutions
Ideal For:
Lipid-based formulations | Self-emulsifying drug delivery systems (SEDDS) | Solid dispersions | Semi-solid formulations | Oil-based drug solutions
Watch the video to see SYLOID® XDP in action
SYLOID® XDP Silica Benefits:
Sample SYLOID® XDP SilicaSYLOID® XDP Silica Benefits:
More API per particle
Smaller dosage forms
More efficient release of API
A novel platform to extend product life-cycle
by transforming liquid dosage forms into solids
Experience the benefits of large particles with true internal porosity.
by transforming liquid dosage forms into solids
Experience the benefits of large particles with true internal porosity.
SYLOID® XDP is specifically designed to convert lipids, oily drugs, and oil-based drug solutions into free-flowing powders without the need for solvents. Optimized for lipid-based delivery systems, it offers high loading capacity while maintaining stability and powder flowability. Its adsorption capabilities make it an effective excipient for a range of applications, including solid dispersions, semi-solid formulations, and lipid-based technologies such as self-emulsifying drug delivery systems (SEDDS).
SYLOID® XDP Silica for Conversion of Oily Actives into Powders
SYLOID® XDP Silica for Conversion of Oily Actives into Powders
Syloid® XDP silicas has been specifically designed for converting lipids, oily drugs, and drugs in oil solutions into free flowing powders. Syloid® XDP silicas can be effective as adsorbents in techniques such as solid dispersion, semi-solids and in lipid-based technologies such as self-emulsifying drug delivery systems (SEDDS).
Benefits:
Benefits:
✔ High loading capacity
✔ Excellent powder flowability
✔ Excellent powder flowability
✔ Efficient API release
✔ Smaller dosage forms
✔ Smaller dosage forms
✔ Improved manufacturing flexibility
✔ Lifecycle extension opportunities*
✔ Lifecycle extension opportunities*
* through dosage-form conversion
Whether the challenge is moisture control, poor flowability, tablet performance, coating optimization, or conversion of oily APIs into solid dosage forms, SYLOID® silica provides multifunctional solutions that simplify formulation development and improve manufacturing performance.
Looking for more information?
See Case Studies on SYLOID® Silica
📊 Case Study:
Using SYLOID® Mesoporous Silica as an Additive to Mitigate
Powder Flow and Static Issues in Micronization Processes
📊 Case Study:
Adding SYLOID® Mesoporous Silica to Improve Run Time
and Yield for Micronization Processes
Download Silica Brochures
⬇️ Multifunctional Excipients for the Pharma and Nutra Industries
Excipients_for_Pharma_and_Nutra.pdf⬇️ Pharmaceutical and Nutraceutical Solutions
⬇️ Download Grace Pharmaceutical Solutions brochure:
Grace's SYLOID FP (Food & Pharma) product line meets the highest levels of global pharmaceutical standards:
✔ Grace meets ICH guidelines for elemental impurities
✔ Complies with USP-NF requirements for Silicon Dioxide
✔ Meets European Pharmacopoeia requirements for Silica, Colloidal Hydrated
✔ Excipients are listed on the FDA Inactive Ingredient Database.
These standards provide formulators with confidence in quality, consistency, and regulatory acceptance throughout product development and commercialization.
Grace is the world's largest manufacturer of specialty silicas, backed by more than 100 years of silica manufacturing expertise and over 45 years of chromatography experience.
We are happy to connect our customers with the right solutions for their formulation challenges. Our portfolio of Grace Syloid Silicas are available on our portal and our team of technical representatives are happy to help you.